[A10218] CAS 2537-48-6 | Diethyl cyanomethylphosphonate, 96% | Alfa
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Brand: Alfa Aesar
2537-48-6 | C6H12NO3P | diethyl cyanomethylphosphonate
Chemical Identifiers
CAS
2537-48-6
Molecular Weight (g/mol)
177.14
Synonym
diethyl cyanomethylphosphonate
SMILES
CCOP(=O)(CC#N)OCC
InChI Key
KWMBADTWRIGGGG-UHFFFAOYSA-N
Molecular Formula
C6H12NO3P
IUPAC Name
diethyl (cyanomethyl)phosphonate
Specifications
Appearance (Color)
Clear colorless to pale yellow
Form
Liquid
Assay (GC)
≥95.0%
Refractive Index
1.4290-1.4350 @ 20?C
설명
Diethyl cyanomethyl phosphonate is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha, beta-unsaturated nitriles from ketones or aldehydes like 3-hydroxy-3-methylbutanal. It reacts with epoxides and nitrones to prepare cyano-substituted cyclopropanes and aziridines respectively. It is actively involved in the synthesis of alpha-arylated alkanenitriles via reaction with aryl iodides in presence of CuI.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Diethyl cyanomethyl phosphonate is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha, beta-unsaturated nitriles from ketones or aldehydes like 3-hydroxy-3-methylbutanal. It reacts with epoxides and nitrones to prepare cyano-substituted cyclopropanes and aziridines respectively. It is actively involved in the synthesis of alpha-arylated alkanenitriles via reaction with aryl iodides in presence of CuI.
Diethyl cyanomethyl phosphonate is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha, beta-unsaturated nitriles from ketones or aldehydes like 3-hydroxy-3-methylbutanal. It reacts with epoxides and nitrones to prepare cyano-substituted cyclopropanes and aziridines respectively. It is actively involved in the synthesis of alpha-arylated alkanenitriles via reaction with aryl iodides in presence of CuI.
Solubility
Miscible with water, chloroform, terahydrofuran, ethyl acetate and methylene chloride.
Notes
Incompatible with acids, bases, oxidizing agents and reducing agents.
Other References:
UN Number:UN3278Beilstein:1772981
GHS Hazard and Precautionary Statements
Hazard Statements:H302+H312+H332-H315-H319-H335
GHS H StatementH331-H302-H312-H315-H319 Toxic if inhaled. Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation.
Precautionary Statements:P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
Risk & Safety
TSCA:No
경고:RUO – Research Use Only
CAS2537-48-6FORMULAC6H12NO3PHAZARD CLASS6.1EINECS219-806-0MDLMFCD00001893PACKAGING GROUPIII
| Pakage | 100g, 25g, 500g |
|---|---|
| brand | Alfa Aesar |
