[22565] CAS 57-83-0 | Progesterone, 98% | Acros

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57-83-0 | C21H30O2 | progesterone proluton glanducorpin prolutone prolutin akrolutin lutocylin lutocylol progesterol pranone

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Chemical Identifiers

CAS
57-83-0
Molecular Weight (g/mol)
314.47
Synonym
progesterone proluton glanducorpin prolutone prolutin akrolutin lutocylin lutocylol progesterol pranone
SMILES
CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI Key
RJKFOVLPORLFTN-LEKSSAKUSA-N
Molecular Formula
C21H30O2
IUPAC Name
(1S,3aS,3bS,9aR,9bS,11aS)-1-acetyl-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one

Specifications

Appearance (Form)
Crystalline powder
Loss on drying
=<0.5 % (500 mg, 105°C, 2 hrs)
Appearance (Color)
White to off-white
Melting point
126°C to 131°C
Specific optical rotation
+186° to +194° (20°C, 589 nm) (c=1, ethanol)

설명

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Progesterone is a sex hormone required for suppression of estrogen signaling and is also involved in transcriptional activation

• Progesterone maintains the uterine endothelium and sustains pregnancy through suppression of muscle contractility

Applications

• Progesterone signaling is relevant to the study of breast cancer

Literature References

Kim, O.; Park, E.Y.; Kwon, S.Y.; Shin, S.; Emerson, R.E.; Shin, Y.H.; DeMayo, F.J.; Lydon, J.P.; Coffey, D.M.; Hawkins, S.M.; Quilliam, L.A.; Cheon, D.J.; Fernández, F.M.; Nephew, K.P.; Karpf, A.R.; Widschwendter, M.; Sood, A.K.; Bast, R.C. Jr.; Godwin, A.K.; Miller, K.D.; Cho, C.H.; Kim, J. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020, 117(50), 31993-32004.

Jain, V.; McDonald, S.D.; Mundle, W.R.; Farine, D. Guideline No. 398: Progesterone for Prevention of Spontaneous Preterm Birth. J Obstet Gynaecol Can. 2020, 42(6), 806-812.

Other References:

Merck Index:15, 7889

GHS Hazard and Precautionary Statements

Hazard Statements:GHS Signal Word: Warning
GHS H Statement: Suspected of causing cancer.
Precautionary Statements:GHS P Statement:
Use personal protective equipment as required.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

Risk & Safety

경고:RUO – Research Use Only

CAS57-83-0FORMULAC21H30O2MDLMFCD00003658

Pakage

100g, 25g, 5g

brand

Acros Organics

SKU: 22565 Category:  Brand:
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[22565] CAS 57-83-0 | Progesterone, 98% | Acros

[22565] CAS 57-83-0 | Progesterone, 98% | Acros

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