[L08775] CAS 68641-49-6 | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride, 97%

CAS : 68641-49-6
UN# : UN1759
MDL : MFCD00010077
Hazard Class : 8
Packing Group : II

Other name :

BOP-Cl

Chemical Properties

Formula : C6H8ClN2O5P
Formula weight : 254.57
Melting Point : ca 195° dec.
Sensitivity : Moisture Sensitive. Ambient temperatures.
Solubility : Hydrolyzes with water.

Literature References

Coupling reagent for which the rates of reaction with various nucleophiles are sufficiently different to permit a genuine “one-step” coupling of carboxylic acids with amines: Synthesis, 547 (1980). Particularly suitable for coupling N-alkyl amino acids: J. Org. Chem., 51, 3350 (1986). For discussion of strategies for one-step coupling in synthesis of amides, see: Synthesis, 413 (1984), and of the scope and limitations of the reagent in peptide coupling, see: Int. J. Pept. Prot. Res., 29, 574 (1987); J. Org. Chem., 55, 2895 (1990). See also Appendix 6. For use in the direct selective 5′-acylation of nucleosides by carboxylic acids, (without 3′-protection), see: Tetrahedron, 44, 229 (1988). For high yield dehydration of carboxylic acids to anhydrides, see: Synthesis, 616 (1981). Also used in macrolide cyclization: J. Am. Chem. Soc., 104, 6818 (1982), and in formation of acyclic esters: Synth. Commun., 14, 515 (1984). The mixed anhydride formed with carboxylic acids adds to imines to give ß-lactams: Synthesis, 63 (1982): These are also formed in high yield by cyclization of ß-amino acids: Bull. Korean Chem. Soc., 12, 457 (1991).

Notes

Moisture Sensitive, store away from moisture. Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.Other References:Beilstein: 3654596UN#: UN1759

Grade Specifications

Grade Specifications

Hazard Statements : H314-H318Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements : P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.