CAS : 478336-92-4
MDL : MFCD22376813
Other name :
(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl esterMacrophage Migration Inhibitory Factor Antagonist
Chemical Properties
Formula : C12H13NO4
Formula weight : 235.24
Sensitivity : Store at -20°C. Light Sensitive. Store under Argon.
Form : Solid
Solubility : Soluble in DMSO.
Applications
MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
Grade Specifications
GHS Hazard and Precautionary Statements
Precautionary Statements :
Precautionary Statements :
위험 문구 :
안전 문구 :
| Pakage | 25mg, 5mg |
|---|---|
| brand | Alfa Aesar |
