[J63895] CAS 23593-75-1 | Clotrimazole

CAS : 23593-75-1
UN# : UN3077
MDL : MFCD00057220
Hazard Class : 9
EINECS : 245-764-8
Packing Group : III

Other name :

1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole1-(o-Chlorotrityl)imidazole

Chemical Properties

Formula : C22H17ClN2
Formula weight : 344.84
Melting Point : 141-149°
Sensitivity : Ambient temperatures.
Form : Powder
Solubility : Soluble in chloroform, DMSO, DMF and alcohols

Applications

Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H302-H315-H319Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.
Precautionary Statements : P280-P305+P351+P338-P302+P352-P321-P362-P501aWear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Take off contaminated clothing and wash before reuse.Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References :

Merck : 14,2417
UN# : UN3077