[J62818] CAS 139481-59-7 | Candesartan, 98%

CAS : 139481-59-7
MDL : MFCD00081076

Chemical Properties

Formula : C24H20N6O3
Formula weight : 440.45
Melting Point : 183-185°
Sensitivity : Ambient temperatures.
Form : Powder
Solubility : Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).

Applications

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.Other References :
Merck : 14,1739

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H311-H332-H315-H319-H335Toxic if swallowed.Toxic in contact with skin.Harmful if inhaled.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P301+P310-P305+P351+P338-P361-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Remove/Take off immediately all contaminated clothing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
위험 문구 : 20/21/22-36/37/38Harmful by inhalation, in contact with skin and if swallowed.Irritating to eyes, respiratory system and skin.
안전 문구 : 9-26-36/37-60Keep container in a well-ventilated place.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.This material and its container must be disposed of as hazardous waste