[J62164] CAS 111470-99-6 | Amlodipine besylate, 98+%, Alfa

CAS : 111470-99-6
MDL : MFCD00887594

Chemical Properties

Formula : C20H25ClN2O5.C6H5SO3H
Formula weight : 567.05
Melting Point : 195-204°
Sensitivity : Ambient temperatures.
Form : Solid
Solubility : Soluble in DMSO (?20 mg/mL), water (10 mM), chloroform, ethanol (?14 mg/mL), and methanol.

Applications

Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.Other References :
Merck : 14,491

GHS Hazard and Precautionary Statements

Hazard Statements : H302-H315-H319-H335Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P305+P351+P338-P302+P352-P321-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
위험 문구 : 22-36/37/38Harmful if swallowed.Irritating to eyes, respiratory system and skin.
안전 문구 : 26-36/37-60In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.This material and its container must be disposed of as hazardous waste