[B21503] CAS 1619-34-7 | 3-Quinuclidinol, 98+%

CAS : 1619-34-7
UN# : UN3259
MDL : MFCD00151326
Hazard Class : 8
EINECS : 216-578-4
Packing Group : II

Other name :

1-Azabicyclo[2.2.2]octan-3-ol3-Hydroxyquinuclidine

Chemical Properties

Formula : C7H13NO
Formula weight : 127.19
Melting Point : 217-224°
Sensitivity : Air Sensitive. Store under Argon. Ambient temperatures.
Form : Crystalline powder
Solubility : Soluble in water.

Literature References

Reagent for selective cleavage of ß-keto esters to ketones in high yield: Synth. Commun., 5, 341 (1975). Geminal diesters are converted to monoesters in high yield under similar conditions: J. Org. Chem., 41, 208 (1976). Superior catalyst for the Baylis-Hillman reaction: the addition of acrylic esters to aldehydes, often very slow (4-7 days) with the usual catalyst 1,4-Diazabicyclo[2.2.2]octane, A14003, is much faster (<1 day) in the presence of quinuclidinol: Synth. Commun., 18, 495 (1988); Tetrahedron Lett., 32, 5611 (1991). For more recent discussion and methodology, see: J. Org. Chem., 67, 510 (2002); 68, 692 (2003). For reviews of the Baylis-Hillman reaction, see: Tetrahedron, 44, 4653 (1988); 52, 8001 (1996). The rate of addition of enones to aldehydes is similarly enhanced: Synth. Commun., 18, 495 (1988); 19, 959 (1989).

Notes

Incompatible with oxidizing agents.Other References:Beilstein: 104327Merck: 14,8082UN#: UN3259

Grade Specifications

Grade Specifications

Hazard Statements : H314-H318Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements : P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.