[B21481] CAS 49844-90-8 | 4-Chloro-2-(methylthio)pyrimidine, 97%

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CAS : 49844-90-8
UN# : UN1760
MDL : MFCD00006083
Hazard Class : 8
EINECS : 256-500-6
Packing Group : II

Other name :

4-Chloro-2-(methylmercapto)pyrimidine

Chemical Properties

Formula : C5H5ClN2S
Formula weight : 160.63
Melting Point : ca -2°
Boiling Point : 118-120°/9mm
Flash point : >110°(230°F)
Density : 1.380
Refractive Index : 1.6 00
Sensitivity : Store at -20°C. Moisture Sensitive. May form a Precipitate.
Form : Liquid
Solubility : Not miscible or difficult to mix in water.

Applications

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H314-H318Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements : P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References :

Beilstein : 118042
UN# : UN1760