[A17871] CAS 433-06-7 | 2,2,2-Trifluoroethyl p-toluenesulfonate, 98+%

CAS : 433-06-7
MDL : MFCD00000443
EINECS : 207-085-5

Other name :

p-Toluenesulfonic acid 2,2,2-trifluoroethyl ester

Chemical Properties

Formula : C9H9F3O3S
Formula weight : 254.23
Melting Point : 37-42°
Boiling Point : 87-92°/0.1mm
Flash point : >110°(230°F)
Sensitivity : Moisture Sensitive. Ambient temperatures.
Form : Crystals

Literature References

Alkylating agent for introduction of the trifluoroethyl group. Metallation by LDA leads to 2,2-difluoro-1-tosyloxyvinyllithium, which adds quantitatively to carbonyl groups. Acid hydrolysis leads to ɑ-tosyloxy acrylates, which can be hydrolyzed to ɑ-keto acids by base: Tetrahedron Lett., 4809 (1978): n-BuLi at -78o has also been used by Ichikawa’s group to generate the vinyllithium intermediate, which undergoes boron or copper mediated reactions yielding 2,2-difluorovinyl ketones and other products. See, e.g.: Tetrahedron Lett., 33, 337 (1992); Tetrahedron, 50, 11637 (1994); J. Org. Chem., 60, 2320 (1995).

Notes

Other References:Beilstein: 2699394

Grade Specifications

Grade Specifications

Hazard Statements : H315-H319-H335Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P305+P351+P338-P302+P352-P321-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.