[A17404] CAS 117-08-8 | Tetrachlorophthalic anhydride, 98%

CAS : 117-08-8
UN# : UN3077
MDL : MFCD00005920
Hazard Class : 9
EINECS : 204-171-4
Packing Group : III

Chemical Properties

Formula : C8Cl4O3
Formula weight : 285.90
Melting Point : 254-258°
Boiling Point : 349-354° Flash point: 362°(683°F)
Sensitivity : Moisture Sensitive. Ambient temperatures.
Form : Crystalline powder
Solubility : Hydrolyzes slowly in water.

Literature References

Protection of amines as their tetrachlorophthalimide derivatives, by reaction with the anhydride in the presence of triethylamine, has been found to be useful in oligosaccharide chemistry. The group is stable to a wide range of reagents but can be selectively cleaved with ethylenediamine at lower temperatures than for the parent phthalimide derivatives; in particular, carboxylic esters are not cleaved under these conditions: J. Am. Chem. Soc., 117, 3302 (1995); J. Org. Chem., 61, 432 (1996).

Applications

Protection of amines as their tetrachlorophthalimide derivatives, by reaction with the anhydride in the presence of triethylamine, has been found to be useful in oligosaccharide chemistry. The group is stable to a wide range of reagents but can be selectively cleaved with ethylenediamine at lower temperatures than for the parent phthalimide derivatives; in particular, carboxylic esters are not cleaved under these conditions.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H334-H317-H318-H400-H410May cause allergy or asthma symptoms or breathing difficulties if inhaled.May cause an allergic skin reaction.Causes serious eye damage.Very toxic to aquatic life.Very toxic to aquatic life with long lasting effects.
Precautionary Statements : P285-P261-P305+P351+P338-P302+P352-P321-P501aIn case of inadequate ventilation wear respiratory protection.Avoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Dispose of contents/container in accordance with local/regional/national/international regulations.Other References:Beilstein: 211560UN#: UN3077