[A15890] CAS 60-24-2 | 2-Mercaptoethanol, 98+%

CAS : 60-24-2
UN# : UN2966
MDL : MFCD00004890
Hazard Class : 6.1
EINECS : 200-464-6
Packing Group : II

Other name :

Thioethylene glycolThioglycol

Chemical Properties

Formula : HSCH2CH2OH
Formula weight : 78.13
Melting Point : -100°
Boiling Point : 156-158°
Flash point : 73°(163°F)
Density : 1.114
Refractive Index : 1.500
Sensitivity : Hygroscopic. Air Sensitive. Ambient temperatures.
Form : Liquid
Solubility : Miscible with water, alcohol, ether, benzene and other organic solvents.

Literature References

Protective agent for preventing oxidation of thiol groups in proteins: Enzyme Assays, R. Eisenthal and M. J. Danson, Eds., OUP, Oxford (1992), p 265. In the presence of BF3 etherate, reacts with carbonyl compounds to give monothioacetals (1,3-oxathiolanes): J. Org. Chem., 33, 2133 (1968). Amberlyst 15 is also effective: Synthesis, 1826 (2001), as is In(OTf)3: Synlett, 1535 (2002). 1,3-Oxathiolanes can be prepared from acid-sensitive aldehydes with LiBH4 as catalyst in acetonitrile: Synlett, 238 (2001). Cleavage can be effected, e.g. with chloramine-T: Tetrahedron Lett., 3445 (1971), isoamyl nitrite: Tetrahedron. Lett., 3561 (1978), or periodic acid: Tetrahedron Lett., 37, 4331 (1996). Selective cleavage of oxathiolanes in the presence of dithiolanes has been achieved with triphenylcarbenium tetrafluoroborate: J. Chem. Soc., Perkin 1, 542 (1972), or 4-nitrobenzaldehyde catalyzed by TMS-OTf: J. Chem. Soc. Chem. Commun., 1937 (1994). Compare 1,2-Ethanedithiol, L12865. 2-Mercaptoethanol is a reagent for the specific cleavage of the N-dithiasuccinimide protecting group from amines. See Chlorocarbonyl­sulfenyl­ chloride, L06432.

Notes

Hygroscopic. Air sensitive and heat sensitive. Incompatible with metals, strong acids, heavy metal salts and oxidizing agents. Store in a cool place.Other References:Beilstein: 773648Merck: 14,5869UN#: UN2966

Grade Specifications

Grade Specifications

Hazard Statements : H301-H310-H315-H317-H335-H318-H400-H410-H227Toxic if swallowed.Fatal in contact with skin.Causes skin irritation.May cause an allergic skin reaction.May cause respiratory irritation.Causes serious eye damage.Very toxic to aquatic life.Very toxic to aquatic life with long lasting effects.Combustible liquid.
Precautionary Statements : P210-P301+P310-P305+P351+P338-P361-P405-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Remove/Take off immediately all contaminated clothing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.