[A15236] CAS 100-11-8 | 4-Nitrobenzyl bromide, 97+%

CAS : 100-11-8
UN# : UN3261
MDL : MFCD00007373
Hazard Class : 8
EINECS : 202-820-6
Packing Group : II

Other name :

alpha-Bromo-4-nitrotoluene

Chemical Properties

Formula : C7H6BrNO2
Formula weight : 216.04
Melting Point : 97-101°
Sensitivity : Ambient temperatures.
Form : Crystalline powder
Solubility : It hydrolyzes in water. Soluble in alcohol and ether.

Literature References

Has been used as a protecting reagent for the carboxyl group in peptide synthesis: Helv. Chim. Acta, 42, 972 (1959); see 4-Nitrobenzyl­ chloride, A15749, and Appendix 6. Has also been used in ß-lactam synthesis. Cleavage by sodium sulfide avoids hydrogenolysis problems otherwise encountered with these sulfur-containing nuclei: J. Org. Chem., 43, 1243 (1978). For the protection of alcohols, introduction of the group by the use of silver oxide has been recommended. Selective cleavage can be accomplished with DDQ (2,3-Dichloro-5,6-dicyanobenzoquinone, A11879) or by anodic oxidation. Many other benzyl-type protecting groups are unaffected by these conditions: Tetrahedron Lett., 31, 389 (1990). Indium metal in the presence of ammonium chloride is an effective deprotection system for 4-nitrobenzyl ethers and esters: J. Chem. Soc., Perkin 1, 955 (2001).

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents, amines, bases and alcohols.Other References:Beilstein: 742796UN#: UN3261

Grade Specifications

Grade Specifications

Hazard Statements : H314-H318Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements : P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.