[A15226] CAS 1874-23-3 | Methyl 5-nitro-2-furoate, 97%

CAS : 1874-23-3
UN# : UN2811
MDL : MFCD00051956
Hazard Class : 6.1
EINECS : 000-000-0
Packing Group : III

Other name :

Methyl 5-nitrofuran-2-carboxylate5-Nitrofuran-2-carboxylic acid methyl ester

Chemical Properties

Formula : C6H5NO5
Formula weight : 171.11
Melting Point : 78-82°
Sensitivity : Ambient temperatures.
Form : Crystalline powder

Literature References

The nitro-group is susceptible to nucleophilic displacement (compare 1,4-Dinitrobenzene, A10293): J. Heterocycl. Chem., 18, 1241 (1981). This has been used as the basis of a synthesis of diaryl ethers involving Diels-Alder addition and decarboxylative aromatization of the adduct: J. Chem. Soc., Perkin 1, 1231 (1990): Undergoes vicarious nucleophilic substitution of hydrogen at the 3-position. For example with chloromethyl phenyl sulfone and base, 2-nitro-3-(phenylsulfonylmethyl)furan is formed in 75% yield: Tetrahedron, 51, 8339 (1995). For analogous example and reaction scheme, see 2-Nitrothiophene, A17464. For a review of vicarious nucleophilic substitution in heterocyclic compounds, see: Synthesis, 103 (1991).

Notes

Other References:Beilstein: 165132UN#: UN2811

Grade Specifications

Grade Specifications

Hazard Statements : H341Suspected of causing genetic defects.
Precautionary Statements : P281-P201-P202-P308+P313-P405-P501aUse personal protective equipment as required.Obtain special instructions before use.Do not handle until all safety precautions have been read and understood.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.