[A11414] CAS 89-00-9 | Pyridine-2,3-dicarboxylic acid, 99%

CAS : 89-00-9
MDL : MFCD00006295
EINECS : 201-874-8

Other name :

Quinolinic acid

Chemical Properties

Formula : C7H5NO4
Formula weight : 167.12
Melting Point : ca 188° dec.
Sensitivity : Ambient temperatures.
Form : Crystalline powder
Solubility : Soluble in water (partly), alkalies, dilute aqueous base, DMSO, and alcohol (slightly).

Applications

Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an “excitotoxic” metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H315-H319-H335Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P305+P351+P338-P302+P352-P321-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References :

Beilstein : 137110Merck : 14,8073