[A11058] CAS 108-75-8 | 2,4,6-Collidine, 99%

CAS : 108-75-8
UN# : UN1992
MDL : MFCD00006338
Hazard Class : 3
EINECS : 203-613-3
Packing Group : III

Other name :

2,4,6-Trimethylpyridine

Chemical Properties

Formula : C8H11N
Formula weight : 121.18
Melting Point : -43°
Boiling Point : 171-172°
Flash point : 54°(129°F)
Density : 0.916
Refractive Index : 1.4980
Sensitivity : Ambient temperatures.
Form : Liquid
Solubility : Slightly miscible with water. Miscible with ether, methanol, acetone, chloroform, benzene, toluene and dilute acids.

Literature References

Hindered base. For use in the dehydrochlorination of ɑ-chloroketones to enones, see: Org. Synth. Coll., 4, 162 (1963). For use in combination with Trifluoromethanesulfonic anhydride, A11767 for the generation of ketenimines from olefins, see N,N-Dimethyl­acetamide, A10924. Superior base for peptide coupling reactions, causing less racemization than the more commonly used N-ethyldiisopropylamine or N-methylmorpholine: J. Org. Chem., 59, 695 (1994). For comparison with other hindered bases, see: J. Org. Chem., 61, 2460 (1996). For peptide reagents, see Appendix 6. Solvent for various O-alkyl cleavage reaction by LiI, including hindered esters: J. Org. Chem., 28, 2184 (1963), and methyl ethers of phenols: Chem. Commun., 616 (1969).

Notes

Incompatible with oxidizing agents and strong acids.Other References:Beilstein: 107283Merck: 14,9718UN#: UN1992

Grade Specifications

Grade Specifications

Hazard Statements : H226-H302-H312-H315-H319-H335Flammable liquid and vapour.Harmful if swallowed.Harmful in contact with skin.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P210-P241-P303+P361+P353-P305+P351+P338-P405-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.Use explosion-proof electrical/ventilating/lighting/ equipment.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.