[A10914] CAS 623-00-7 | 4-Bromobenzonitrile, 98+%

CAS : 623-00-7
MDL : MFCD00001811
EINECS : 210-764-9

Other name :

4-Cyanobromobenzene

Chemical Properties

Formula : C7H4BrN
Formula weight : 182.03
Melting Point : 111-114°
Boiling Point : 235-237°
Flash point : 130°(266°F)
Density : 1.562
Sensitivity : Ambient temperatures.
Form : Crystalline powder
Solubility : Very slightly soluble in water(0.2g/L). Soluble in alcohol and ether.

Applications

4-Bromobenzonitrile is used as reagents and solvents. Reaction of 2-propanol, 4-bromobenzonitrile, and NaH in the presence of 1.5 mol % Pd2(dba)3 and 3 mol % (S)-(-)2,2?-bis(di-p-tolylphosphino)- 1,1?-binaphthyl at 50°C afforded 4-isopropoxy- benzonitrile in 80% isolated yield. The synthesis of 4-cyanobiphenyl at room temperature in a flow injection microreactor, using a supported catalyst, without the addition of a base gave a product yield of 67±7% (n=6). This was achieved by injecting 4-bromobenzonitrile. The 3-arylation of 2,5-dimethylthiophene with 4-bromopropiophenone, 4-trifluoromethylbromobenzene or 4-bromobenzonitrile gave 3-5 in only 38-50% yields in Palladium-catalysed direct 3-or 4-arylation of thiophene derivatives using aryl bromides.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H331-H312-H315-H319-H335-H402-H412Toxic if swallowed.Toxic if inhaled.Harmful in contact with skin.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.Harmful to aquatic life.Harmful to aquatic life with long lasting effects.
Precautionary Statements : P261-P301+P310-P305+P351+P338-P302+P352-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References :

Beilstein : 2041518