[A10479] CAS 770-12-7 | Phenyl phosphorodichloridate, 97%

CAS : 770-12-7
UN# : UN3265
MDL : MFCD00002067
Hazard Class : 8
EINECS : 212-220-6
Packing Group : II

Other name :

Phenyl dichlorophosphate

Chemical Properties

Formula : C6H5Cl2O2P
Formula weight : 210.98
Melting Point : -1°
Boiling Point : 241-243°
Flash point : 112°(233°F)
Density : 1.415
Refractive Index : 1.5230
Sensitivity : Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Form : Liquid
Solubility : Immiscible with water.

Literature References

Reagent for the preparation of phosphate diesters. The phenyl group is removable by hydrogenolysis: J. Am. Chem. Soc., 75, 4510 (1953). Coupling reagent, e.g. in pyridine for the preparation of derivatives of sulfinic acids with alcohols, amines, thiols etc.: Synthesis, 937 (1980). Similarly, carboxylic acids in pyridine can be coupled with thiols to give thiocarboxylic acid S-esters: Can. J. Chem., 58, 2645 (1980), and with sodium azide in the presence of a phase-transfer catalyst to give acyl azides: Synth. Commun., 13, 289 (1983). Reacts with the Li enolates of ß-diketones, in the presence of LiCl, to give ß-chloro-ɑß-enones: Can. J. Chem., 64, 520 (1986). In combination with NaI, cleaves dialkyl ethers to iodides in high yield: Synth. Commun., 18, 119 (1988), and 1,3-dithianes and other dithioacetals to carbonyl groups: Tetrahedron Lett., 29, 5471 (1988). In combination with Dimethyl­ sulfoxide, A13280, effects selective oxidation of alcohols to aldehydes or ketones with less ɑ-chlorination than the more usual Swern (Oxalyl­ chloride, A18012) system: J. Org. Chem., 52, 5621 (1987). Similarly, benzylamines have been converted to benzaldehydes: Synth. Commun., 19, 3407 (1989). For a brief feature on uses of the reagent in synthesis, see: Synlett, 1651 (2004).

Notes

Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong bases, alcohols and strong oxidizing agents.Other References:Beilstein: 511863UN#: UN3265

Grade Specifications

Grade Specifications

Hazard Statements : H301-H310-H314-H318Toxic if swallowed.Fatal in contact with skin.Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements : P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Remove/Take off immediately all contaminated clothing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.