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[J61707] CAS 129-46-4 | Suramin hexasodium salt, 98+% | Alfa

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Brand: Alfa Aesar

129-46-4 | J61707

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설명

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Chemical Identifiers

Specifications

Chemical Name or Material
Suramin hexasodium salt
CAS
129-46-4
Color
White
Recommended Storage
Keep cold
RTECS Number
QM7000000

설명

Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and tumor cell metastasis. Inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 ?M along with SIRT5 has also been observed. Suramin Sodium has been recorded to antagonize EDG-3 (S1P3) selectively. Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4, PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF. It is used as a G protein uncoupler and inhibitor of PDGF, EGF, TGF-β, SIRT1 and SIRT5. It also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Suramin is a polysulphonated napthylurea which exhibits anti-parasitic and anticancer properties

• Suramin prevents endothelial cell migration and proliferation through inhibition of IGF-I, EGF, PDGF, and TGF-beta

• Suramin can also uncouple G-proteins from receptors and turn off cell signaling cascades

Application

• Suramin inhibits angiogenesis through blockade of bFGF and VEGF and can be useful for the laboratory study of blood vessel growth and renewal following injury

• Suramin inhibits DNA topoisomerases, and can be used as an antineoplastic agent in the laboratory study of cancer or for studies of microbial physiology

Other References:

Merck Index:14,9006Beilstein:3694087

GHS Hazard and Precautionary Statements

Hazard Statements:

Risk & Safety

TSCA:NoRTECS Number:QM7000000

경고:RUO – Research Use Only

EINECS204-949-3MDLMFCD00210217

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Pakage

1g, 250mg, 500MG
brand

Alfa Aesar
SKU: J61707 Category:  Brand:
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[J61707] CAS 129-46-4 | Suramin hexasodium salt, 98+% | Alfa

[J61707] CAS 129-46-4 | Suramin hexasodium salt, 98+% | Alfa

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