[J62734] CAS 33069-62-4 | Paclitaxel, 99.5+% | Alfa
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Brand: Alfa Aesar
33069-62-4 | C47H51NO14 | paclitaxel
Chemical Identifiers
CAS
33069-62-4
Molecular Weight (g/mol)
853.92
Synonym
paclitaxel
SMILES
CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1
InChI Key
RCINICONZNJXQF-VAZQATRQSA-N
Molecular Formula
C47H51NO14
IUPAC Name
(1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate
Specifications
Appearance (Color)
White to cream
Assay from Suppliers CofA
≥99.5% (HPLC)
Form
Crystalline powder or granular
설명
Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. It is used to treat certain types of cancer such as ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It interferes with the growth of cancer cells and slows down their growth and spread in the body. It is also used to treat AIDS-related Kaposi’s sarcoma.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Paclitaxel is a tetracyclic diterpenoid isolated from the Pacific yew, Taxus brevifolia
- Paclitaxel acts as an antineoplastic agent by binding tubulin and preventing cell division
- Paclitaxel may also bind Bcl-2 and lead to disinhibition of apoptosis
Application
- Paclitaxel is used in the study of lung, breast, and ovarian cancers; it may be useful in the research of other cancer types
- It is suitable for cell culture, biochemistry, and molecular biology applications
Other References:
Merck Index:14,6982Beilstein:1420457
GHS Hazard and Precautionary Statements
Hazard Statements:H302+H312+H332-H318-H334-H335-H361
GHS H StatementH334-H341-H361-H318-H302-H312-H332-H335-H315-H317 May cause allergy or asthma symptoms or breathing difficulties if inhaled.Suspected of causing genetic defects.Suspected of damaging fertility or the unborn child.Causes serious eye damage.Harmful if swallowed.Harmful in contact with skin.Harmful if inhaled.May cause respiratory irritation.Causes skin irritation.May cause an allergic skin reaction.
Precautionary Statements:P201-P202-P261-P264b-P270-P271-P281-P285-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P312-P330-P342+P311-P363-P501c
Risk & Safety
TSCA:NoRTECS Number:DA8340700
경고:RUO – Research Use Only
CAS33069-62-4FORMULAC47H51NO14MDLMFCD00869953
| Pakage | 100mg, 1g, 500MG |
|---|---|
| brand | Alfa Aesar |
