[J63575] CAS 15318-45-3 | Thiamphenicol | Alfa
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Brand: Alfa Aesar
15318-45-3 | C12H15Cl2NO5S | thiamphenicol armai (TN) thiocymetin (TN) (+)-thiamphenicol 甲砜霉素
Chemical Identifiers
CAS
15318-45-3
Molecular Weight (g/mol)
356.21
Synonym
thiamphenicol armai (TN) thiocymetin (TN) (+)-thiamphenicol 甲砜霉素
SMILES
CS(=O)(=O)C1=CC=C(C=C1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl
InChI Key
OTVAEFIXJLOWRX-NXEZZACHSA-N
Molecular Formula
C12H15Cl2NO5S
IUPAC Name
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide
Specifications
Appearance (Color)
White to yellow
Sulfated Ash
≤0.5%
Assay from Suppliers CofA
≥97.0%
Form
Powder or crystals or crystalline powder
Loss on Drying
≤1.0%
설명
Thiamphenicol is used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Thiamphenicol is used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
Thiamphenicol is used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
Solubility
Soluble in acetonitrile or DMF. Slightly soluble in water
Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
Other References:
Merck Index:14,9301Beilstein:2819542
GHS Hazard and Precautionary Statements
Hazard Statements:
Risk & Safety
TSCA:NoRTECS Number:AB6680000
경고:RUO – Research Use Only
CAS15318-45-3FORMULAC12H15Cl2NO5SEINECS239-355-3MDLMFCD00467983
| Pakage | 1g, 25g, 5g |
|---|---|
| brand | Alfa Aesar |
