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[J63916] CAS 16561-29-8 | Phorbol 12-myristate 13-acetate, 95% | Alfa

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Brand: Alfa Aesar

16561-29-8 | C36H56O8 | phorbol ester tpa (phorbol derivative) tpa (tetradecanoylphorbol acetate) PMA tetradecanoylphorbol acetate, 4a α isomer factor A1 4a α isomer tetradecanoylphorbol acetate myristate acetate, phorbol acetate, tetradecanoylphorbol phorbol-myristate acetate

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설명

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Chemical Identifiers

CAS
16561-29-8
Molecular Weight (g/mol)
616.84
Synonym
phorbol ester tpa (phorbol derivative) tpa (tetradecanoylphorbol acetate) PMA tetradecanoylphorbol acetate, 4a α isomer factor A1 4a α isomer tetradecanoylphorbol acetate myristate acetate, phorbol acetate, tetradecanoylphorbol phorbol-myristate acetate
SMILES
CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O
InChI Key
PHEDXBVPIONUQT-RGYGYFBISA-N
Molecular Formula
C36H56O8
IUPAC Name
(1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,⁶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate

Specifications

Appearance (Color)
White to pale cream
Assay from Suppliers CofA
≥94.0%
Form
Powder, film or foam, solid

설명

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.

Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Other References:

Merck Index:14,7332Beilstein:2407201

GHS Hazard and Precautionary Statements

Hazard Statements:H315-H319-H335
GHS H StatementH315 Causes skin irritation.
Precautionary Statements:P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Risk & Safety

TSCA:NoRTECS Number:QH4377000

경고:RUO – Research Use Only

CAS16561-29-8FORMULAC36H56O8MDLMFCD00036736PACKAGING GROUPI

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Pakage

10MG, 1mg, 25mg, 5mg
brand

Alfa Aesar
SKU: J63916 Category:  Brand:
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[J63916] CAS 16561-29-8 | Phorbol 12-myristate 13-acetate, 95% | Alfa

[J63916] CAS 16561-29-8 | Phorbol 12-myristate 13-acetate, 95% | Alfa

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