[J64083] CAS 2392-39-4 | Dexamethasone 21-phosphate disodium salt, 98% | Alfa
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Brand: Alfa Aesar
2392-39-4 | C22H28FNa2O8P | dalalone sodium dexamethasone phosphate
Chemical Identifiers
CAS
2392-39-4
Molecular Weight (g/mol)
516.41
Synonym
dalalone sodium dexamethasone phosphate
SMILES
[Na+].[Na+].C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP([O-])([O-])=O
InChI Key
PLCQGRYPOISRTQ-FCJDYXGNSA-L
Molecular Formula
C22H28FNa2O8P
IUPAC Name
disodium (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-2,9a,11a-trimethyl-1-[2-(phosphonatooxy)acetyl]-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
Specifications
Appearance (Color)
White to pale cream
Form
Crystals or powder or crystalline powder
Assay from Suppliers CofA
≥97.5%
설명
Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Dexamethasone 21-phosphate disodium salt is a sodium phosphate salt form of dexamethasone, considered to be a synthetic adrenal glucocorticoid with anti-inflammatory activity
Application
Dexamethasone 21-phosphate disodium salt binds to specific nuclear steroid receptors, interfering with NF-kB activation and apoptotic pathways
It acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter
It has been used as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 in the induced reactivation and spontaneous shedding rabbit models
This compound is used to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs
Other References:
Merck Index:142943Beilstein:6473066
GHS Hazard and Precautionary Statements
Hazard Statements:Acute toxicity (category 4), Reproductive toxicity (category 2), Specific target organ toxicity after repeated exposure (category 2)
Harmful if swallowed, Suspected of damaging the unborn child, May cause damage to organs through prolonged or repeated exposure
Risk & Safety
TSCA:YesRTECS Number:TU4056000
경고:RUO – Research Use Only
CAS2392-39-4FORMULAC22H28FNa2O8PEINECS219-243-0MDLMFCD00079105
| Pakage | 1g, 5g |
|---|---|
| brand | Alfa Aesar |
