[J64859] CAS 1609651-90-2 | Acetylene-PEG4-maleimide | Alfa
0 ₩
Brand: Alfa Aesar
1609651-90-2 | J64859
Chemical Identifiers
Specifications
Proton NMR
Conforms
Appearance (Color)
Colorless liquid, may contain off-white crystals upon standing
Assay from Supplier’s CofA
≥94.0% (HPLC, ELSD)
Form
Liquid, may crystallize upon standing
설명
Heterobifunctional cross linker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character. A bifunctional linker with sulfhydryl reactive and azide reactive groups. Contains a PEG spacer to increase solubility
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Heterobifunctional cross linker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character. A bifunctional linker with sulfhydryl reactive and azide reactive groups. Contains a PEG spacer to increase solubility
Heterobifunctional cross linker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character. A bifunctional linker with sulfhydryl reactive and azide reactive groups. Contains a PEG spacer to increase solubility
Solubility
Soluble in water.
Notes
Keep container tightly closed. Store away from oxidizing agents.
GHS Hazard and Precautionary Statements
Hazard Statements:H315-H319-H335
GHS H StatementH315-H319-H335 Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements:P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
Risk & Safety
TSCA:No
경고:RUO – Research Use Only
MDLMFCD22380740
| Pakage | 100mg, 25mg |
|---|---|
| brand | Alfa Aesar |
