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SKU |
02150175-CF |
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Application Notes |
It is typically used as a coating substrate for culture dishes, slides, etc. It enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Both the D- and L- form of the poly-lysine can be used as a coating substrate since poly-lysine is a nonspecific attachment factor for cells; however, certain cells can digest poly-lysine. In this case, poly-D-lysine should be used as the attachment factor so that the cells are not disrupted by excessive uptake of L-lysine.Other uses for poly-lysine have been reported as well:• Conjugation to methotrexate for increased drug transport.• Microencapsulation of islets.• Use in simple reproducible procedure for chromosomal preparations from a variety of tissues.• Immobilation of living cells in biocompatible semipermeable microcapsules.• In the preparation of polycationic beads.• Conjugation to albumin and horseradish peroxidase to enhance cellular uptake. |
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Base Catalog Number |
150175 |
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Biochemical Physiological Actions |
Poly-D-lysine hydrobromide is a synthetic amino acid that enhances cell adhesion to solid substrates. It has additionally been shown to eliminate prion proteins from infected cells. |
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CAS # |
27964-99-4 |
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Personal Protective Equipment |
Eyeshields, Gloves,respirator filter |
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Usage Statement |
Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
