02155957-CF | CAS 1476-53-5 | Novobiocin, sodium salt | MPBIO
Key Features and Details
Novobiocin Sodium Salt
| SKU | 02155957-CF |
| Alternate Names | Albamycin; Cathomycin sodium |
| Application Notes | For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.Novobiocin is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA. |
| Base Catalog Number | 155957 |
| Biochemical Physiological Actions | Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.Antimicrobial spectrum: Gram-positive bacterial.Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitors of the ATPase reaction catalysed by GyrB 2. It is also a Hsp90 inhibitor 3. Antimicrobial spectrum: Gram-positive bacterial. |
| CAS # | 1476-53-5 |
| EC Number | 216-023-6 |
| Extinction Coefficient | E1%= 600 (0.1 M NAOH) |
| Format | Powder |
| Molecular Formula | C31H35N2O11Na |
| Molecular Weight | 634.614 g/mol |
| Optical Rotation | -38.0°(2.5 g/100 ml ethanol at24°C for the free acid) |
| Potency | ~900 µg/mg |
| RTECS Number | RD5425000 |
| Typical Working Concentration | The minimum inhibitory concentration (MIC) toward gram-positive bacteria is 0.1 to 4 µg/ml |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| UV Visible Absorbance | λmax: 307 nm |
