02190287-CF | CAS 143-67-9 | Vinblastine sulfate | MPBIO
Key Features and Details
Vinblastine Sulfate
| SKU | 02190287-CF |
| Alternate Names | VLB; Vincaleukoblastine sulfate salt |
| Application Notes | Vinblastine Sulfate is used in cancer research. |
| Base Catalog Number | 190287 |
| Beilstein Registry Number | 3659812 |
| Biochemical Physiological Actions | Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4. |
| CAS # | 143-67-9 |
| EC Number | 205-606-0 |
| Format | Powder |
| Hazard Statements | H302-H315-H318-H335 |
| Melting Point | 543 to 545° F (NTP, 1992) |
| Molecular Formula | C46H60N4O13S |
| Molecular Weight | 909.061 g/mol |
| RTECS Number | YY8400000 |
| Safety Symbol | GHS05, GHS07 |
| Solubility | greater than or equal to 10 mg/mL at 76.1° F (NTP, 1992) |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
