|
SKU |
02193919-CF |
|
Alternate Names |
Chloroquinone Phosphate;N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt |
|
Application Notes |
Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. DNA intercalator. Also used to increase transfection efficiency. |
|
Base Catalog Number |
193919 |
|
Beilstein Registry Number |
4223142 |
|
Biochemical Physiological Actions |
Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ (N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide). |
|
CAS # |
50-63-5 |
|
EC Number |
200-055-2 |
|
Hazard Statements |
H302 |
|
Melting Point |
87 deg C |
|
Molecular Formula |
C18H26N3Cl • 2H3PO4 |
|
Molecular Weight |
515.865 g/mol |
|
Personal Protective Equipment |
Dust mask type , Eyeshields, Gloves |
|
pKa |
4.0 – 5.0 |
|
Potency |
8.4 and 10.8 (for chloroquine base at 20 °C) |
|
RTECS Number |
VB2450000 |
|
Solubility |
VERY SLIGHTLY SOL IN <a class=”pubchem-internal-link CID-962″ href=”https://pubchem.ncbi.nlm.nih.gov/compound/WATER”>WATER</a>; SOL IN DIL ACIDS, <a class=”pubchem-internal-link CID-6212″ href=”https://pubchem.ncbi.nlm.nih.gov/compound/CHLOROFORM”>CHLOROFORM</a>, ETHER |
|
Source |
Soluble in water. Practically insoluble in alcohol; benzene; chloroform and ether. |
|
Storage |
BIOCHEMICALS |
|
Unit Definition |
Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 µM |
|
Usage Statement |
Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
|
Vapor Pressure |
5.0X10-9 mm Hg at 25 deg C (est) |
