[02193919-CF] CAS 50-63-5 | Chloroquine diphosphate salt | MP bio
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02193919-CF | CAS 50-63-5 | Chloroquine diphosphate salt | MPBIO
Key Features and Details
- Antibiotic
- Antimalarial compound
| SKU | 02193919-CF |
| Alternate Names | Chloroquinone Phosphate;N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt |
| Application Notes | Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. DNA intercalator. Also used to increase transfection efficiency. |
| Base Catalog Number | 193919 |
| Beilstein Registry Number | 4223142 |
| Biochemical Physiological Actions | Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ (N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide). |
| CAS # | 50-63-5 |
| EC Number | 200-055-2 |
| Hazard Statements | H302 |
| Melting Point | 87 deg C |
| Molecular Formula | C18H26N3Cl • 2H3PO4 |
| Molecular Weight | 515.865 g/mol |
| Personal Protective Equipment | Dust mask type , Eyeshields, Gloves |
| pKa | 4.0 – 5.0 |
| Potency | 8.4 and 10.8 (for chloroquine base at 20 °C) |
| RTECS Number | VB2450000 |
| Solubility | VERY SLIGHTLY SOL IN <a class=”pubchem-internal-link CID-962″ href=”https://pubchem.ncbi.nlm.nih.gov/compound/WATER”>WATER</a>; SOL IN DIL ACIDS, <a class=”pubchem-internal-link CID-6212″ href=”https://pubchem.ncbi.nlm.nih.gov/compound/CHLOROFORM”>CHLOROFORM</a>, ETHER |
| Source | Soluble in water. Practically insoluble in alcohol; benzene; chloroform and ether. |
| Storage | BIOCHEMICALS |
| Unit Definition | Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 µM |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Pressure | 5.0X10-9 mm Hg at 25 deg C (est) |
