[44956] CAS 147-94-4 | Cytarabine, 98%
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Brand: Acros Organics
147-94-4 | C9H13N3O5 | cytarabine ara-C cytarabine liposome injection cytarbel arabitin cytosar-U β-arabinosylcytosine citarabina [inn-spanish] cytarabinoside cytosine arabinofuranoside
Chemical Identifiers
CAS
147-94-4
Molecular Weight (g/mol)
243.22
Synonym
cytarabine ara-C cytarabine liposome injection cytarbel arabitin cytosar-U β-arabinosylcytosine citarabina [inn-spanish] cytarabinoside cytosine arabinofuranoside
SMILES
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
InChI Key
UHDGCWIWMRVCDJ-CCXZUQQUSA-N
Molecular Formula
C9H13N3O5
IUPAC Name
4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
Specifications
Appearance (Form)
Crystalline powder
HPLC
>=97.5 %
Appearance (Color)
White to Beige
Infrared spectrum
Conforms
Specific optical rotation
+155° to +162° (20°C, 589 nm) (c=1, water)
설명
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Cytarabine is a nucleoside analog that acts as an antileukemic agent
Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha
Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells
Applications
Has been used to study chemotherapeutic regimens in laboratory studies of leukemia
Useful for laboratory studies of cytarabine resistance mechanisms
At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members
It can induce neuronal cell death via inducing γ-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks
Other References:
Merck Index:152781
GHS Hazard and Precautionary Statements
Hazard Statements:Serious eye damage/eye irritation (category 2), Germ cell mutagenicity (category 2), Reproductive toxicity (category 2), Skin sensitisation (category 1)
Causes serious eye irritation, Suspected of causing genetic defects, Suspected of damaging fertility or the unborn child, May cause an allergic skin reaction
Risk & Safety
경고:RUO – Research Use Only
CAS147-94-4FORMULAC9H13N3O5
| Pakage | 100mg, 1g, 5g |
|---|---|
| brand | Acros Organics |
