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[B21459] CAS 10238-21-8 | Glybenzcyclamide, 99% | Alfa

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Brand: Alfa Aesar

10238-21-8 | C23H28ClN3O5S | glyburide glimide semi-euglucon abbenclamide gilemal glibenclamid heumann glibenclamid-ratiopharm glycolande renabetic semi-daonil

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Chemical Identifiers

CAS
10238-21-8
Molecular Weight (g/mol)
494.00
Synonym
glyburide glimide semi-euglucon abbenclamide gilemal glibenclamid heumann glibenclamid-ratiopharm glycolande renabetic semi-daonil
SMILES
COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1
InChI Key
ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Molecular Formula
C23H28ClN3O5S
IUPAC Name
5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide

Specifications

Appearance (Color)
White
Form
Crystals or powder or crystalline powder
Assay (Aqueous acid-base Titration)
≥98.5 to ≤101.5% (non-U.S. specification)
Assay from Suppliers CofA
≥98.5% (U.S. specification)
Comment
Specification differs for U.S. and non-U.S. material where indicated

설명

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 M).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 μM).

Solubility
Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 – 8°C. Keep away from strong oxidizing agents.

GHS Hazard and Precautionary Statements

Hazard Statements:

Risk & Safety

TSCA:No

경고:RUO – Research Use Only

CAS10238-21-8FORMULAC23H28ClN3O5SEINECS233-570-6MDLMFCD00056625

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Pakage

100g, 25g
brand

Alfa Aesar
SKU: B21459 Category:  Brand:
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[B21459] CAS 10238-21-8 | Glybenzcyclamide, 99% | Alfa

[B21459] CAS 10238-21-8 | Glybenzcyclamide, 99% | Alfa

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