[A17129] CAS 491-36-1 | 4-Hydroxyquinazoline, 98% | Alfa
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Brand: Alfa Aesar
491-36-1 | C8H6N2O | quinazolinone
Chemical Identifiers
CAS
491-36-1
Molecular Weight (g/mol)
146.15
Synonym
quinazolinone
SMILES
O=C1N=CNC2=CC=CC=C12
InChI Key
QMNUDYFKZYBWQX-UHFFFAOYSA-N
Molecular Formula
C8H6N2O
IUPAC Name
1,4-dihydroquinazolin-4-one
Specifications
Appearance (Color)
White to cream
Form
Crystals or crystalline powder or needles or flakes or chunks
Assay (Non-aqueous acid-base Titration)
≥97.5 to ≤102.5%
Assay (HPLC)
≥97.5%
설명
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
Solubility
Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
Other References:
Beilstein:118473
GHS Hazard and Precautionary Statements
Hazard Statements:H302-H315-H319-H335
GHS H StatementH302-H315-H319-H335Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements:P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
Risk & Safety
TSCA:NoRTECS Number:VA2300000
경고:RUO – Research Use Only
CAS491-36-1FORMULAC8H6N2OEINECS207-735-8MDLMFCD00511302
| Pakage | 10g, 50G |
|---|---|
| brand | Alfa Aesar |
