02100557-CF | CAS 18883-66-4 | Streptozotocin | MPBIO
Key Features and Details
Streptozotocin
| SKU | 02100557-CF |
| Alternate Names | N-(Methylnitrosocarbamoyl)-α-D-glucosamine; Streptozocin; STZ; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose |
| Application Notes | Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors. |
| Base Catalog Number | 100557 |
| Beilstein Registry Number | 2060675 |
| Biochemical Physiological Actions | An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter. |
| CAS # | 18883-66-4 |
| EC Number | 242-646-8 |
| Extinction Coefficient | EmM(228 nm): 6.36 (ethanol) |
| Format | Powder |
| Half Life | biological half-life in cell culture medium was shown to be approximately 19 minutes. |
| Hazard Statements | H350 |
| Melting Point | 239° F (Decomposes) (NTP, 1992) |
| Molecular Formula | C8H15N3O7 |
| Molecular Weight | 265.222 g/mol |
| Personal Protective Equipment | Eyeshields, full-face particle respirator type N100, Gloves, respirator cartridge, respirator filter |
| Purity | ~75% α-anomer basis; ≥97% |
| RTECS Number | LZ5775000 |
| Safety Symbol | GHS06+GHS08 |
| Solubility | Soluble (NTP, 1992) |
| Typical Working Concentration | Has been used in intravenous injections in rats at a dose of 65 mg/kg body weight to induce diabetes (using cold 0.1 M citrate buffer pH 4.5). In rats and dogs, diabetes was induced using intravenous dosage of 50 mg/kg body weight (using 1-2% w/v solutions in saline buffered with citrate dextrose solution at pH 5.0). |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
