02104658-CF | CAS 50-76-0 | Actinomycin D, ~98% | MPBIO
Key Features and Details
Actinomycin D
| SKU | 02104658-CF |
| Alternate Names | Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; Meractinomycin; Actinomycin AIV; Actinomycin IV; Actinomycin C1; Actinomycin X1; NSC-3053; Cosmegen |
| Application Notes | Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm’s tumour and the sarcomas. |
| Base Catalog Number | 104658 |
| Beilstein Registry Number | 605235 |
| Biochemical Physiological Actions | Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase. |
| CAS # | 50-76-0 |
| EC Number | 200-063-6 |
| Format | Crystalline powder |
| Hazard Statements | H300 |
| Melting Point | 467 to 469° F (decomposes) (NTP, 1992) |
| Molecular Formula | C62H86N12O16 |
| Molecular Weight | 1255.438 g/mol |
| Personal Protective Equipment | Eyeshields, Faceshields, Full-face particle respirator, Gloves, Respirator cartridge, Respirator filter |
| Purity | 98% |
| RTECS Number | AU1575000 |
| Safety Symbol | GHS06 |
| Solubility | Soluble at 50° F (NTP, 1992) |
| Source | Streptomyces parvalus |
| Typical Working Concentration | 1 µg/mL |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Pressure | 0 mm Hg at 25 deg C (est) |
