|
SKU |
02194157-CF |
|
Alternate Names |
Polymyxin E, Colistin sulphate salt |
|
Application Notes |
Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii. It has been used to study hephrotoxicity in the rat kidney, and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa. |
|
Base Catalog Number |
194157 |
|
Biochemical Physiological Actions |
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity. Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH. |
|
CAS # |
1264-72-8 |
|
EC Number |
215-034-3 |
|
Hazard Statements |
H301 |
|
Molecular Weight |
1253.527 g/mol |
|
Personal Protective Equipment |
Eyeshields, Faceshields, Gloves, respirator cartridges |
|
RTECS Number |
TR1500000 |
|
Specific Activity |
≥15,000 u/mg |
|
Usage Statement |
Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
