[A11668] CAS 563-41-7 | Semicarbazide hydrochloride, 99%

CAS : 563-41-7
UN# : UN2811
MDL : MFCD00013009
Hazard Class : 6.1
EINECS : 209-247-0
Packing Group : III

Chemical Properties

Formula : CH4N3O•HCl
Formula weight : 111.53
Melting Point : ca 176° dec.
Sensitivity : Ambient temperatures.
Form : Crystalline
Solubility : Soluble in water (>100g/L).

Literature References

Derivatizing agent for carbonyl compounds as their semicarbazones. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid: Tetrahedron, 37, 843 (1981). Other reagents for the cleavage of semicarbazones include: Amberlyst� 15 in aqueous acetone: J .Chem. Soc., Perkin 1, 2563 (1988); Dowex� 50 in aqueous suspension: J. Org. Chem., 53, 878 (1988); CuSO4 in aqueous THF: J. Prakt. Chem., 322 1063 (1980).

Applications

Semicarbazide hydrochloride is used as urease substrate and MAO inhibitor. Derivatizing agent for carbonyl compounds as their semicarbazones which produces crystalline compounds with characteristic melting points. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H315-H319-H335Toxic if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P301+P310-P305+P351+P338-P302+P352-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.Other References:Beilstein: 3593642Merck: 14,8444UN#: UN2811