CAS : 300-87-8
UN# : UN1993
MDL : MFCD00003156
Hazard Class : 3
EINECS : 206-100-2
Packing Group : III
Chemical Properties
Formula : C5H7NO
Formula weight : 97.12
Melting Point : -14°
Boiling Point : 142-144° Flash point: 31°(87°F)
Density : 0.992
Refractive Index : 1.4415
Sensitivity : Ambient temperatures.
Form : Liquid
Solubility : Insoluble in water.
Literature References
Lithiation occurs first at the 5-methyl group. Subsequent reaction with electrophiles can be followed by further lithiation of the 3-methyl, providing a route to substituted isoxazoles, and also to 1,3-diketones by acid hydrolysis or ß-aminoketones by hydrogenolysis: Tetrahedron Lett., 22, 3699 (1981): Review: Reaction of 3,5-dimethylisoxazole with some electrophiles: Heterocycles, 6, 805 (1977).
Applications
The optimization of 3,5-dimethylisoxazole derivatives to develop potent inhibitors of the BET (bromodomain and extra terminal domain) bromodomain family with good ligand efficiency. It has hypoglycemic activity.
Grade Specifications
GHS Hazard and Precautionary Statements
Hazard Statements : H226Flammable liquid and vapour.
Precautionary Statements : P210-P241-P280-P303+P361+P353-P403+P235-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.Use explosion-proof electrical/ventilating/lighting/ equipment.Wear protective gloves/protective clothing/eye protection/face protection.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.Store in a well-ventilated place. Keep cool.Dispose of contents/container in accordance with local/regional/national/international regulations.Other References:Beilstein: 106324UN#: UN1993
| Pakage | 100g, 25g |
|---|---|
| brand | Alfa Aesar |
