[A13724] CAS 16357-59-8 | 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%

CAS : 16357-59-8
MDL : MFCD00006703
EINECS : 240-418-2

Other name :

EEDQN-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

Chemical Properties

Formula : C14H17NO3
Formula weight : 247.29
Melting Point : 63-66°
Boiling Point : 125-128°/0.1mm
Sensitivity : Moisture Sensitive. Keep Cold.
Form : Powder
Solubility : Soluble in 95% Ethanol (50 mg/ml). Insoluble in water.

Literature References

Reagent for peptide coupling. Reaction proceeds via the anhydride of the acid component: J. Am. Chem. Soc., 90, 823, 1651 (1968); Int. J. Pept. Prot. Res., 26, 493 (1985). See Appendix 6. For activation of ɑ -hydroxy acids, see: Tetrahedron Lett, 40, 3435 (1999) . Also used for the mild esterification of alcohols, e.g. for introduction of the levulinate protecting group (see Levulinic acid, A10813): Tetrahedron Lett., 23, 2615 (1982). For a useful esterification technique applicable to primary, secondary and tertiary alcohols, see: J. Org. Chem., 60, 7072 (1995).

Notes

Moisture Sensitive. Store at 4°C. Incompatible with acids and strong oxidizing agents.Other References:Beilstein: 533048Merck: 14,3518

Grade Specifications

Grade Specifications

Hazard Statements : H315-H319-H335Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P305+P351+P338-P302+P352-P321-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.