[A13776] CAS 87-13-8 | Diethyl ethoxymethylenemalonate, 98+% | Alfa
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Brand: Alfa Aesar
87-13-8 | C10H16O5 | 1,3-diethyl 2-(ethoxymethylidene)propanedioate
Chemical Identifiers
CAS
87-13-8
Molecular Weight (g/mol)
216.23
Synonym
1,3-diethyl 2-(ethoxymethylidene)propanedioate
SMILES
CCOC=C(C(=O)OCC)C(=O)OCC
InChI Key
LTMHNWPUDSTBKD-UHFFFAOYSA-N
Molecular Formula
C10H16O5
IUPAC Name
1,3-diethyl 2-(ethoxymethylidene)propanedioate
Specifications
Identification (FTIR)
Conforms
Appearance (Color)
Clear colorless
Assay (GC)
≥98.0%
Refractive Index
1.4605-1.4645 @ 20?C
Form
Liquid
설명
Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.
Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.
Solubility
Miscible with chloroform, dichloromethane and methanol. Immiscible with water.
Notes
Incompatible with acids, bases, oxidizing agents and reducing agents.
Other References:
Beilstein:880058
GHS Hazard and Precautionary Statements
Hazard Statements:H302-H314-H317-H334-H335
GHS H StatementH334-H315-H319-H317May cause allergy or asthma symptoms or breathing difficulties if inhaled.Causes skin irritation.Causes serious eye irritation.May cause an allergic skin reaction.
Precautionary Statements:P260-P264b-P270-P271-P272-P280-P285-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P501c
Risk & Safety
TSCA:YesRTECS Number:OO1100000
경고:RUO – Research Use Only
CAS87-13-8FORMULAC10H16O5EINECS201-725-7MDLMFCD00009148
| Pakage | 1000g, 100g, 250g, 50G, 500g |
|---|---|
| brand | Alfa Aesar |
