[A14688] CAS 530-62-1 | 1,1′-Carbonyldiimidazole, 97%

CAS : 530-62-1
UN# : UN3259
MDL : MFCD00005286
Hazard Class : 8
EINECS : 208-488-9
Packing Group : II

Other name :

CDI

Chemical Properties

Formula : C7H6N4O
Formula weight : 162.15
Melting Point : 116-120°
Sensitivity : Moisture Sensitive. Store under Argon. Ambient temperatures.
Form : Crystalline powder
Solubility : Soluble in dimethylformamide.

Literature References

Reagent for peptide coupling via the acylimidazolide: Liebigs Ann. Chem., 609, 75 (1957); J. Am. Chem. Soc., 80, 4423 (1958); 82, 4596 (1960): J. Org. Chem., 27, 2094 (1962). For peptide reagents, see Appendix 6. One-pot esterification of a carboxylic acid with t-BuOH occurs in the presence of DBU: Synthesis, 833 (1982). The reactivity of acyl imidazolides can be increased by N-alkylation: Chem. Pharm. Bull., 32, 5044 (1984). Acylimidazolides can also be reduced to aldehydes by DIBAL-H. This reaction has been applied to N-protected amino acids: J. Chem. Soc., Chem. Commun., 79 (1979). Dehydrates aldoximes, including chiral oximes, to nitriles in high yield: J. Chem. Soc., Chem. Commun., 628 (1973); Synth. Commun., 12, 25 (1982). Ketoximes can be converted to amides by the spontaneous Beckmann rearrangement of imidazolium salts: Chem. Pharm. Bull., 32, 2560 (1984): ß-Hydroxy amino acids are dehydrated to dehydroamino acids: Synthesis, 968 (1982). ɑß-Dihydroxyketones are converted toɑ-diketones: Synth. Commun., 23, 2219 (1993).

Notes

Store in a cool place. Incompatible with water, strong acids, strong oxidizing agents, strong bases and amines.Other References:Beilstein: 6826Merck: 14,1819UN#: UN3259

Grade Specifications

Grade Specifications

Hazard Statements : H301-H314-H318Toxic if swallowed.Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements : P260-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.