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[A15393] CAS 305-01-1 | 6,7-Dihydroxycoumarin, 98+% | Alfa

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Brand: Alfa Aesar

305-01-1 | C9H6O4 | esculetin esculetol asculetine cichoriin aglycon esculin aglycon aesculetin cichorigenin cichoriin aglucon esculatin esculin aglucon

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설명

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Chemical Identifiers

CAS
305-01-1
Molecular Weight (g/mol)
178.14
Synonym
esculetin esculetol asculetine cichoriin aglycon esculin aglycon aesculetin cichorigenin cichoriin aglucon esculatin esculin aglucon
SMILES
OC1=C(O)C=C2C=CC(=O)OC2=C1
InChI Key
ILEDWLMCKZNDJK-UHFFFAOYSA-N
Molecular Formula
C9H6O4
IUPAC Name
6,7-dihydroxy-2H-chromen-2-one

Specifications

Appearance (Color)
Cream to yellow to pale brown
Form
Crystals or powder or crystalline powder
Assay (HPLC)
≥98.0%

설명

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.

Other References:

Merck Index:14,3697Beilstein:152788

GHS Hazard and Precautionary Statements

Hazard Statements:H315-H319-H335
GHS H StatementH315-H319-H335Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements:P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Risk & Safety

TSCA:NoRTECS Number:GN6382500

경고:RUO – Research Use Only

CAS305-01-1FORMULAC9H6O4EINECS206-161-5MDLMFCD00006874

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Pakage

1g, 5g
brand

Alfa Aesar
SKU: A15393 Category:  Brand:
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[A15393] CAS 305-01-1 | 6,7-Dihydroxycoumarin, 98+% | Alfa

[A15393] CAS 305-01-1 | 6,7-Dihydroxycoumarin, 98+% | Alfa

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