[A15398] CAS 5470-11-1 | Hydroxylamine hydrochloride, 99%

CAS : 5470-11-1
UN# : UN2923
MDL : MFCD00051089
Hazard Class : 8
EINECS : 226-798-2
Packing Group : III

Other name :

Hydroxylammonium chloride

Chemical Properties

Formula : H3NO•HCl
Formula weight : 69.49
Melting Point : 152° dec.
Density : 1.67
Sensitivity : Hygroscopic. Ambient temperatures.
Form : Crystals
Solubility : Soluble in water, alcohol, methanol and glycerol.

Literature References

For examples of preparation of oximes from carbonyl compounds, see: Org. Synth. Coll., 2, 70, 313 (1955); 7, 149 (1990). Dehydration of aldoximes is a valuable route to nitriles. The preparation of an oxime, and dehydration with acetic anhydride, are exemplified for veratraldehyde: Org. Synth. Coll., 2, 622 (1943). For other methods of dehydrating oximes to nitriles, see Benzaldoxime, A12053. Procedures for the one-pot conversion of aldehydes to nitriles, without isolation of the intermediate oxime, include: refluxing the aldehyde with hydroxylamine hydrochloride in formic acid/ sodium acetate: J. Chem. Soc., 1564 (1965); formic acid alone: Synthesis, 112 (1979); in pyridine and toluene, with azeotropic water removal: Synthesis, 190 (1982); in DMF (reflux; aromatics only): Z. Chem., 15, 302 (1975); heating in NMP at 110-115o, effective for aromatic and aliphatic substrates; under these conditions, DMF gave only 20-30% conversion: Synthesis, 586 (1999). A more recent ambient temperature one-pot procedure utilizes DBU in combination with ethyl dichlorophosphate: Synlett, 1317 (2007). For a one-pot synthesis of pyrazoles from aldehydes by cyclization of the intermediate oxime in acidic medium with potassium dihyrogen phosphate, see: Tetrahedron Lett., 47, 43 (2006). For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 1326 (2007).

Notes

Air and moisture sensitive. Incompatible with strong oxidizing agents, phosphorous pentachloride, calcium and anhydrous copper(II) sulfate.Other References:Beilstein: 3539763Merck: 14,4828UN#: UN2923

Grade Specifications

Grade Specifications

Hazard Statements : H200-H351-H373-H290-H315-H319-H400-H302-H312-H317Unstable explosives.Suspected of causing cancer.May cause damage to organs through prolonged or repeated exposure.May be corrosive to metals.Causes skin irritation.Causes serious eye irritation.Very toxic to aquatic life.Harmful if swallowed.Harmful in contact with skin.May cause an allergic skin reaction.
Precautionary Statements : P280h-P273-P406Wear protective gloves/clothing.Avoid release to the environment.Store in corrosive resistant container with a resistant inner liner.