[A15603] CAS 2033-24-1 | Isopropylidene malonate, 97% | Alfa
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Brand: Alfa Aesar
2033-24-1 | C6H8O4 | meldrum’s acid
Chemical Identifiers
CAS
2033-24-1
Molecular Weight (g/mol)
144.13
Synonym
meldrum’s acid
SMILES
CC1(C)OC(=O)CC(=O)O1
InChI Key
GXHFUVWIGNLZSC-UHFFFAOYSA-N
Molecular Formula
C6H8O4
IUPAC Name
2,2-dimethyl-1,3-dioxane-4,6-dione
Specifications
Appearance (Color)
White to pale brown
Identification (FTIR)
Conforms
Assay (Aqueous acid-base Titration)
≥96.0% to ≤104.0%
Melting Point (clear melt)
88-97°C
Form
Crystals or crystalline powder
설명
Isopropylidene malonate is an important reagent in synthetic chemistry and involved in the formation of new C-C bonds, rings, amides, esters, and acids. The presence of carbonyl groups at C-4 and C-6 positions favors the alkylation and acylation reactions due to its acidic nature. It is also employed as an antimicrobial agent. It is used in the preparation of 4-pyridyl-substituted heterocycles, 2-substituted indoles, isofraxidin and macrocyclic beta-keto lactones. Further, it is involved in the Knoevenagel condensation reaction with aldehydes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Isopropylidene malonate is an important reagent in synthetic chemistry and involved in the formation of new C-C bonds, rings, amides, esters, and acids. The presence of carbonyl groups at C-4 and C-6 positions favors the alkylation and acylation reactions due to its acidic nature. It is also employed as an antimicrobial agent. It is used in the preparation of 4-pyridyl-substituted heterocycles, 2-substituted indoles, isofraxidin and macrocyclic beta-keto lactones. Further, it is involved in the Knoevenagel condensation reaction with aldehydes.
Isopropylidene malonate is an important reagent in synthetic chemistry and involved in the formation of new C-C bonds, rings, amides, esters, and acids. The presence of carbonyl groups at C-4 and C-6 positions favors the alkylation and acylation reactions due to its acidic nature. It is also employed as an antimicrobial agent. It is used in the preparation of 4-pyridyl-substituted heterocycles, 2-substituted indoles, isofraxidin and macrocyclic beta-keto lactones. Further, it is involved in the Knoevenagel condensation reaction with aldehydes.
Solubility
Soluble in water. Slightly soluble in ethanol and chloroform.
Notes
Store in a cool place. Incompatible with strong oxidizing agents.
Other References:
Merck Index:14,5817Beilstein:117310
GHS Hazard and Precautionary Statements
Hazard Statements:H315
GHS H StatementH315-H319-H335Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements:P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362
Risk & Safety
TSCA:YesRTECS Number:JH0800000
경고:RUO – Research Use Only
CAS2033-24-1FORMULAC6H8O4HAZARD CLASS9EINECS217-992-8MDLMFCD00006638PACKAGING GROUPIII
| Pakage | 100g, 25g, 500g |
|---|---|
| brand | Alfa Aesar |
