[A15857] CAS 641-70-3 | 3-Nitrophthalic anhydride, 97%
0 ₩
641-70-3 |
CAS : 641-70-3
MDL : MFCD00005921
EINECS : 211-373-6
Chemical Properties
Formula : C8H3NO5
Formula weight : 193.11
Melting Point : 161-166°
Sensitivity : Moisture Sensitive. Ambient temperatures.
Form : Crystalline powder
Solubility : May decompose in water.
Literature References
Has been used as an N-blocking group for amino acids in solid-phase peptide synthesis, providing an acidic ‘handle’ allowing separation by ion-exchange chromatography: Angew. Chem. Int. Ed., 8, 764 (1969). See Appendix 6.
Applications
4-Nitrophthalic Anhydride is an intermediate for the synthesis of the benzimidazole PARP inhibitor I, ABT-472. It reacts with aminoquinazolinones to yield phthalimidoquinazolinones.
Grade Specifications
GHS Hazard and Precautionary Statements
Hazard Statements : H315-H319-H335Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P305+P351+P338-P302+P352-P321-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.Other References:Beilstein: 179963
| Pakage | 100g, 25g |
|---|---|
| brand | Alfa Aesar |
