[A16281] CAS 7646-85-7 | Zinc chloride, anhydrous, 98%

CAS : 7646-85-7
UN# : UN2331
MDL : MFCD00011295
Hazard Class : 8
EINECS : 231-592-0
Packing Group : III

Chemical Properties

Formula : Cl2Zn
Formula weight : 136.29
Melting Point : 290°
Boiling Point : 732°
Density : 2.91
Sensitivity : Hygroscopic. Ambient temperatures.
Form : Crystalline solid
Solubility : Soluble in water, dilute HCl, alcohol, glycerol, acetone and ether.

Literature References

Mild Lewis acid catalyst in a wide variety of reactions. Catalyst for the Hoesch reaction for the acylation of reactive aromatics with nitriles. For an example, see: Org. Synth. Coll., 2, 522 (1943). Effective catalyst for the Knoevenagel condensation; see: Tetrahedron Lett., 32, 5821 (1991). Milder catalyst than Titanium(IV)­ chloride, 14713, for the ɑ-tert-alkylation of sensitive silyl enol ethers: Chem. Ber., 113, 3734 (1980). Reacts with NaBH4 in ether or THF to give zinc borohydride; Zn(BH4)2, which is used in situ as a versatile, non-basic, selective reducing agent. Review: Synlett, 885 (1993). The reactivity of Zn(BH4)2 has the advantage of being relatively non-toxic. See, e.g.: Selective reduction of aldehydes in the presence of ketones: Tetrahedron Lett., 31, 7663 (1990). Reduction of aliphatic esters to alcohols: Indian J. Chem B, 31B, 701 (1992). Reduction of indoles to indolines: Heterocycles, 26, 1771 (1987). In combination with trifluoroacetic anhydride for the selective reduction of acids to alcohols: J. Chem. Soc., Perkin 1, 1561 (1992). The same reduction has also been performed by Zn(BH4)2 alone in refluxing THF: J. Org. Chem., 60, 5314 (1995). In combination with paraformaldehyde, for reductive alkylation of amines: J. Chem. Soc., Perkin 1, 1 (1994).

Applications

Zinc chloride is used as a catalyst, dehydrating and condensing agent, soldering flux, and metal etchant. It is also employed in preserving anatomical specimens, wood preservatives, deodorant, disinfecting and embalming materials. It is likewise employed as a mordant in printing and dyeing materials and in the vulcanizing processes of fiber and rubber. It is useful as an electrolyte in dry cell batteries, in metal industry, in galvanizing iron and as an electrolyte for electroplating. It is useful in organic synthesis, for example, in the Friedel-Crafts acylatoin, Fisher indole synthesis, Lucas reagent (zinc chloride with HCl), activation of allylic/benzylic halides towards reaction with olefins or with sodium cyanoborohydride catalyzed reduction of halides, organozinc reagents for use in Negishi coupling, and aldol condensation reactions.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H314-H400-H410-H302Causes severe skin burns and eye damage.Very toxic to aquatic life.Very toxic to aquatic life with long lasting effects.Harmful if swallowed.
Precautionary Statements : P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.Other References:Merck: 14,10132UN#: UN2331