[A16580] CAS 106-96-7 | Propargyl bromide, 80% in toluene, stab. with MgO

CAS : 106-96-7
UN# : UN3286
MDL : MFCD00000241
Hazard Class : 3
EINECS : 203-447-1
Packing Group : II

Other name :

3-Bromo-1-propyne

Chemical Properties

Formula : HC≡CCH2Br
Formula weight : 118.97
Melting Point : -61°
Boiling Point : 88-90°
Flash point : 3°(37°F)
Density : 1.335
Refractive Index : 1.4940
Sensitivity : Keep Cold. Light Sensitive.
Form : Liquid
Solubility : Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.

Applications

Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H225-H301-H335-H336-H304-H361-H373-H314Highly flammable liquid and vapour.Toxic if swallowed.May cause respiratory irritation.May cause drowsiness or dizziness.May be fatal if swallowed and enters airways.Suspected of damaging fertility or the unborn child.May cause damage to organs through prolonged or repeated exposure.Causes severe skin burns and eye damage.
Precautionary Statements : P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References :

Beilstein : 605309
UN# : UN3286