CAS : 29943-42-8
UN# : UN1224
MDL : MFCD00006581
Hazard Class : 3
EINECS : 249-967-2
Packing Group : III
Chemical Properties
Formula : C5H8O2
Formula weight : 100.12
Boiling Point : 165-167° Flash point: 62°(144°F)
Density : 1.084
Refractive Index : 1.4530
Sensitivity : Ambient temperatures.
Form : Liquid
Solubility : Very soluble in water.
Literature References
The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran, L02731, that no new asymmetric center is introduced on reaction with a chiral alcohol: J. Am. Chem. Soc., 89, 3366 (1967); Tetrahedron, 26, 1023, 1031 (1970).
Applications
It is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes. The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. It is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. It is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3
Grade Specifications
GHS Hazard and Precautionary Statements
Hazard Statements : H227Combustible liquid.
Precautionary Statements : P210-P280-P370+P378a-P403+P235-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.Wear protective gloves/protective clothing/eye protection/face protection.In case of fire: Use for extinction: CO2, powder or water spray.Store in a well-ventilated place. Keep cool.Dispose of contents/container in accordance with local/regional/national/international regulations.Other References:Beilstein: 106463UN#: UN1224
| Pakage | 1g, 25g, 5g |
|---|---|
| brand | Alfa Aesar |
