[A19910] CAS 53-86-1 | Indomethacin, 98% | Alfa
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Brand: Alfa Aesar
53-86-1 | C19H16ClNO4 | indomethacin methazine indo-lemmon indomethacin preparation inacid hydrochloride, indomethacin argun C19H16ClNO4 indaflex novo-methacin
Chemical Identifiers
CAS
53-86-1
Molecular Weight (g/mol)
357.79
Synonym
indomethacin methazine indo-lemmon indomethacin preparation inacid hydrochloride, indomethacin argun C19H16ClNO4 indaflex novo-methacin
SMILES
COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1
InChI Key
CGIGDMFJXJATDK-UHFFFAOYSA-N
Molecular Formula
C19H16ClNO4
IUPAC Name
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
Specifications
Assay (Aqueous acid-base Titration)
≥97.5 to ≤102.5%
Melting Point (clear melt)
156.0-163.0?C
Form
Powder
Appearance (Color)
White to pale cream
Assay (HPLC)
≥97.5%
설명
It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in acetone (40 mg/mL – clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL – clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
Soluble in acetone (40 mg/mL – clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL – clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
Notes
Store away from oxidizing agents, strong bases and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
Other References:
Merck Index:14,4968UN Number:UN2811Beilstein:497341
GHS Hazard and Precautionary Statements
Hazard Statements:H300-H317-H360FD
GHS H StatementH300-H341Fatal if swallowed.Suspected of causing genetic defects.
Precautionary Statements:P201-P202-P261-P264b-P270-P272-P280g-P281-P301+P310-P302+P352-P308+P313-P330-P333+P313-P363-P501c
Risk & Safety
TSCA:YesRTECS Number:NL3500000
경고:RUO – Research Use Only
CAS53-86-1FORMULAC19H16ClNO4HAZARD CLASS6.1EINECS200-186-5MDLMFCD00057095PACKAGING GROUPII
| Pakage | 100g, 25g, 5g |
|---|---|
| brand | Alfa Aesar |
