[B21522] CAS 1694-92-4 | 2-Nitrobenzenesulfonyl chloride, 97%, Alfa

CAS : 1694-92-4
UN# : UN3261
MDL : MFCD00007430
Hazard Class : 8
EINECS : 216-907-1
Packing Group : II

Chemical Properties

Formula : C6H4ClNO4S
Formula weight : 221.62
Melting Point : 64-69°
Sensitivity : Moisture Sensitive. Ambient temperatures.
Form : Crystalline powder
Solubility : Soluble in toluene, tetrahydrofuran, methylene chloride, ethyl acetate and dimethylformamide. Insoluble in water.

Literature References

Reagent for formation of 2-nitrobenzenesulfonyl derivatives of alcohols and amines, e.g. in the presence of triethylamine. Selective cleavage with PhSH occurs without displacement of the nitro group which sometimes occurs with the 4-nitro isomer (see following entry): Tetrahedron Lett., 36, 6373 (1995). See also 2-Nitrobenzenesulfonamide, A15689.

Applications

2-Nitrobenzenesulfonyl chloride acts as a reagent to form 2-nitrobenzenesulfonyl derivatives of alcohols and amines. It is also involved in the selective cleavage with thiophenol without displacement of the nitro group. Further, it is used in the preparation of renin inhibitors. In addition to this, it finds application as an anticonvulsant.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H314-H318Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements : P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.Other References:Beilstein: 521155UN#: UN3261