[B21698] CAS 64-77-7 | Tolbutamide, 98% | Alfa
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Brand: Alfa Aesar
64-77-7 | C12H18N2O3S | tolbutamide dolipol orinase diagnostic drabet restinon willbutamide diabetamid tolylsulfonylbutylurea orezan tolbutamida
Chemical Identifiers
CAS
64-77-7
Molecular Weight (g/mol)
270.35
Synonym
tolbutamide dolipol orinase diagnostic drabet restinon willbutamide diabetamid tolylsulfonylbutylurea orezan tolbutamida
SMILES
CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1
InChI Key
JLRGJRBPOGGCBT-UHFFFAOYSA-N
Molecular Formula
C12H18N2O3S
IUPAC Name
3-butyl-1-(4-methylbenzenesulfonyl)urea
Specifications
Assay (Aqueous acid-base Titration)
≥97.5 to ≤102.5% (UK-sourced material)
Assay (HPLC)
≥97.5%
Comment
Material sourced in UK and US
Assay from Supplier’s CofA
≥97.5% (US-sourced material)
Melting Point (clear melt)
126-130°C
설명
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.
Solubility
Soluble in chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
Other References:
Merck Index:14,9507Beilstein:1984428
GHS Hazard and Precautionary Statements
Hazard Statements:H302-H317
GHS H StatementH302-H317Harmful if swallowed.May cause an allergic skin reaction.
Precautionary Statements:P261-P264b-P270-P272-P280g-P301+P312-P302+P352-P330-P333+P313-P363-P501c
Risk & Safety
TSCA:YesRTECS Number:YS4550000
경고:RUO – Research Use Only
CAS64-77-7FORMULAC12H18N2O3SEINECS200-594-3MDLMFCD00027169
| Pakage | 10g, 250g, 50G |
|---|---|
| brand | Alfa Aesar |
