[B25251] CAS 128625-52-5 | 1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%

CAS : 128625-52-5
UN# : UN3077
MDL : MFCD00077411
Hazard Class : 9
EINECS : 000-000-0
Packing Group : III

Other name :

PyBOP®

Chemical Properties

Formula : C18H28F6N6OP2
Formula weight : 520.40
Melting Point : ca 155° dec.
Sensitivity : Keep Cold. Moisture Sensitive.
Form : Crystalline powder
Solubility : Soluble in chloroform.

Literature References

Low racemization peptide coupling reagent (see Appendix 6), introduced by Castro, analogous to BOP Reagent (1H-Benzotriazol-1-yl­oxytris(dimethyl­amino)­phosphonium hexafluorophosphate, A16140) but avoiding the formation of the carcinogenic HMPA as a by-product: Tetrahedron Lett., 31, 205 (1990). For use in formation of mixed phosphonate diesters, see: J. Org. Chem., 60, 5214 (1995).

Notes

Store in a cool place. Incompatible with oxidizing agents and water.Other References:Beilstein: 3584612UN#: UN3077

Grade Specifications

Grade Specifications

Hazard Statements : H315-H319-H335Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P305+P351+P338-P302+P352-P321-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.